We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
Read More
9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
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9
Omega-3s improve cholesterol parameters
Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats.
We examined how swapping a saturated fat diet for omega-3 polyunsaturated fatty acids (n-3PUFAs) affects cholesterol and bone health in hypercholesterolemic rats.
In our study, rats that shifted to an n-3PUFA diet saw a notable decrease in serum lipids. While the diet appeared to positively impact their bone loss linked to periodontitis, rats on the n-3PUFA diet showed results similar to those on a commercial diet, indicating no major advantage of fish oil over a balanced diet.
Overall, our findings suggest that while omega-3s can help with cholesterol, they don't offer significant improvements over typical diets in these conditions.
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Most Useful Reviews
9
Enhanced vitality
120 people found this helpful
The best and most beneficial Omega-3! With a high concentration of EPA and DHA, it conveniently provides the daily dosage in just one capsule, without unpleasant aftereffects. Omega-3, essential for the body, improves immunity, alleviates depression and anxiety, and strengthens the nervous system. I feel healthier and more secure. My quality of life has significantly improved. Take it regularly for optimum benefits, and be healthy!
Read More
9
Goodbye bad cholesterol
93 people found this helpful
My family prefers this omega for daily consumption. The EPA and DHA content is impressive at 900, and it has effectively helped lower my bad cholesterol.
Read More
9
Rich in omega benefits
32 people found this helpful
This omega boasts a rich composition and exceptional quality. It helps lower blood cholesterol, reduces blood clot risks, and delivers various health benefits. The review highlights omega's positive impact on brain function and the immune system. If you match your diet with omega-3, you can enjoy its health advantages.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
Read More
9
CA-rich fish oils lower cholesterol
Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis.
We investigated whether cetoleic acid (CA), a healthy fat found in certain fish, can help lower cholesterol levels in rodents. Our systematic review included 12 studies, assessing how CA-rich fish oils influenced total cholesterol compared to regular diets.
The results showed a significant reduction in cholesterol levels in rodents that consumed CA-rich oils. However, it’s important to note that the risk of bias in the studies varied, making our conclusions tentative. Overall, these findings suggest CA-rich fish oils could play a beneficial role in heart health, but further research in humans is needed.
Read More
9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
Omega-3 effective for heart risk
The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention.
We examined the role of eicosapentaenoic acid (EPA), specifically icosapent ethyl, in reducing cardiovascular disease risks. Approved by the FDA, this omega-3 treatment showed a notable 25% reduction in major heart events for high-risk patients. These patients already had controlled cholesterol but elevated triglyceride levels.
Importantly, while EPA proved effective, mixed omega-3 products lacking substantial evidence for heart health did not provide the same benefits. We believe adding EPA-only formulations to cardiovascular prevention guidelines is essential for at-risk individuals.
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9
8-HEPE benefits cholesterol management
8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice.
We explored how 8-hydroxyeicosapentaenoic acid (8-HEPE), derived from Pacific krill, could improve cholesterol levels in mice commonly used for dyslipidemia studies.
Over eighteen weeks, mice on a high-cholesterol diet receiving 8-HEPE showed significantly higher levels of good HDL cholesterol, alongside lower levels of bad LDL cholesterol and liver triglycerides.
This suggests that 8-HEPE may enhance lipid profiles and liver health by influencing certain genes in macrophages. While promising, further research is needed to confirm these benefits in humans.
The best and most beneficial Omega-3! With a high concentration of EPA and DHA, it conveniently provides the daily dosage in just one capsule, without unpleasant aftereffects. Omega-3, essential for the body, improves immunity, alleviates depression and anxiety, and strengthens the nervous system. I feel healthier and more secure. My quality of life has significantly improved. Take it regularly for optimum benefits, and be healthy!
Read More
9
Goodbye bad cholesterol
93 people found this helpful
My family prefers this omega for daily consumption. The EPA and DHA content is impressive at 900, and it has effectively helped lower my bad cholesterol.
Read More
9
Rich in omega benefits
32 people found this helpful
This omega boasts a rich composition and exceptional quality. It helps lower blood cholesterol, reduces blood clot risks, and delivers various health benefits. The review highlights omega's positive impact on brain function and the immune system. If you match your diet with omega-3, you can enjoy its health advantages.
Read More
7.5
Overall health improvement
9 people found this helpful
An effective product! I recommend it to everyone! The advantages include improved cardiovascular health by reducing blood pressure and cholesterol levels, decreasing the risk of heart attack, and enhancing skin appearance. It combats joint issues and regulates inflammation, which helps with conditions like osteoarthritis and improves nervous system function.
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9
Supports cardiovascular health
6 people found this helpful
This omega-3 is outstanding! It improves brain function and cardiovascular health, lowers bad cholesterol, enhances skin and hair health, and boosts immunity. I take it each morning as my nutritionist advised.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has been widely discussed for its potential benefits in managing cardiovascular health, including high cholesterol. Research indicates that omega-3 fatty acids, particularly EPA and DHA found in fish oil, can help lower triglyceride levels—a type of fat in the blood that contributes to high cholesterol. In some cases, these fatty acids may also raise levels of HDL (high-density lipoprotein), often referred to as "good" cholesterol. However, while omega-3s can be a beneficial part of a heart-healthy diet, they are not a stand-alone solution for cholesterol management.
It's essential to understand that fish oil supplementation should not replace standard cholesterol-lowering medications or lifestyle changes like diet and exercise. Consult with a healthcare professional before adding omega-3 supplements to your regimen, especially if you have existing health conditions or are taking other medications. Keeping a balanced diet rich in omega-3s from sources like fatty fish, flaxseeds, and walnuts can also support overall health and align with cholesterol management goals.
Based on user reviews, the timeline for seeing results from taking omega-3 supplements for high cholesterol varies among individuals. Many users report noticeable improvements within three to six months of consistent use. For instance, one user mentioned that their husband’s cholesterol levels returned to normal after three months of utilizing this supplement Read Review. Another user saw a significant reduction in cholesterol after six months of taking two capsules daily, with further improvements noted as they increased dosage over time Read Review.
Users often emphasize the importance of consistency in supplementation, suggesting that maintaining regular intake can enhance results. One reviewer highlighted that despite initial doubts, increasing to three capsules daily led to remarkable benefits, indicating that dosage adjustments could also play a crucial role in achieving optimal results Read Review. Overall, while individual results may differ, a commitment to regular consumption over a few months appears imperative to realize the full health benefits of omega-3 for cholesterol management.
Research supports the use of several types of omega-3 fatty acids and oils, including krill and fish oils, in managing high cholesterol. For instance, a study on Antarctic krill oil found that it helped reduce fat accumulation and promote healthier cholesterol metabolism in mice, suggesting its potential for managing cholesterol levels related to obesity and metabolic health [1]. Furthermore, the effectiveness of fish oil has been highlighted in various studies; one investigation showed significant reductions in liver triglyceride and cholesterol levels for subjects supplemented with fish oil compared to a control group [2].
In addition, the consumption of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid found in fish oil, has shown promising results in clinical trials for lowering triglycerides significantly and potentially reducing cardiovascular events in high-risk patients [12]. However, it's worth noting that there are mixed results in different studies about the impact of omega-3s on cholesterol, pointing to the need for further research to solidify their benefits [6]. Overall, certain omega-3 supplements appear to be beneficial for cholesterol management, but the effectiveness may vary depending on individual health aspects and dietary contexts.
Based on user reviews, many users report a range of notable improvements in their symptoms after taking omega-3 supplements. Several individuals have highlighted significant reductions in cholesterol levels. For example, one user noted that their husband saw his cholesterol return to normal after three months of use Read Review. Another user recorded a decrease from a cholesterol reading of 7.2 to 4.5 within six months Read Review. Additionally, changes in triglyceride levels were frequently mentioned, with multiple reviewers indicating successful drops from high levels to normal ranges Read Review.
Users consistently communicate benefits beyond cholesterol management, including enhanced cardiovascular health, better skin appearance, and alleviated joint issues. Improvements in overall vitality, such as increased energy levels and better mental clarity, were also reported, with one individual attributing reduced fatigue and sleep issues to regular omega-3 use Read Review. While these testimonials reflect positive experiences, individual results may vary, and prospective users should maintain realistic expectations regarding the outcomes of their supplementation.
Based on user reviews, many individuals have successfully combined omega-3 supplements with other dietary enhancements to manage high cholesterol effectively. For instance, one reviewer noted that taking Omega-3 alongside CoQ10, collagen, and hyaluronic acid resulted in substantial health benefits, particularly in lowering cholesterol levels—a primary concern for them Read Review. Another user mentioned that regular intake, coupled with lifestyle adjustments, led to normalized cholesterol levels after consistent use. This emphasizes the potential benefits of integrating omega-3 with a broader health regime Read Review.
Furthermore, users highlight the necessity of maintaining consistency in supplementation for optimal results. One reviewer attested to the importance of regular consumption along with dietary adjustments, as they observed significant improvements in cholesterol levels over three months of use Read Review. The combination of lifestyle changes with omega-3 supplementation seems crucial, with several users noting that a diet matched with omega-3 enhances the supplement’s health advantages Read Review. While results may vary among individuals, these testimonials underline the synergistic potential of combining omega-3 supplements with other health measures.
When it comes to finding the right dose of Omega-3 fish oil for managing high cholesterol, research suggests that higher doses of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can yield significant benefits. In a study lasting 12 weeks, participants taking varying doses of Omega-3s noted a remarkable reduction in triglycerides—up to 15.78%—indicating that a higher intake could be more effective for cholesterol management [11]. Additionally, another trial highlighted the advantages of icosapent ethyl, a specific formulation of fish oil, demonstrating substantial reductions in ischemic events among patients with high triglycerides [12].
For those considering Omega-3s, a good starting point could be around 1,000 mg of combined EPA and DHA daily. It's essential to consult with a healthcare professional who can provide personalized recommendations based on individual health needs. Remember, while Omega-3 fish oil can be a supportive addition to a cholesterol management plan, it works best when combined with other lifestyle changes such as a balanced diet and regular physical activity.
9
Normalised cholesterol levels
5 people found this helpful
My husband had a high cholesterol level, so I tried this product. After three months of use, his cholesterol levels returned to normal during a follow-up test. While we need to adjust our eating habits, his results give credit to this supplement.
9
Significant cholesterol reduction
3 people found this helpful
Best Omega-3 Fish Oil ever! My family and I have taken this omega fish oil for two years and we absolutely love it. It contains the highest EPA (600) I've encountered and has helped reduce my cholesterol levels from 7.2 to 4.5 within six months of taking two capsules daily. I increased to three capsules a day, and my levels dropped further to 4.0. Now I take four capsules daily, and my cholesterol is around 3.8. I have every confidence it will lower further with time. The benefits of taking this daily are clear, and there's no fishy aftertaste. I’m thoroughly satisfied!
9
Increased energy
5 people found this helpful
After initially not seeing any effects, increasing my intake to three capsules daily led to remarkable results. My energy levels improved significantly; even my mother has more stamina for housework.
9
Normal test results
4 people found this helpful
My husband had significantly elevated triglycerides and cholesterol levels, but after taking two capsules daily, his tests returned to normal. I highly recommend this product.
9
Effective cholesterol lowering
1 people found this helpful
900 acids in one capsule! The dosage is excellent, one capsule suffices daily. I take it with Q10, collagen, and hyaluronic acid each morning, and the benefits are substantial, especially in lowering cholesterol, which is my primary concern. Highly recommended!
9
Cholesterol control
1 people found this helpful
Best value for money Omega 3! I recommend it to everyone. I've been taking it for three years, realising how essential omega-3s are as I age. The packaging is great and its effects are very good, particularly in managing my cholesterol. However, consistency in consumption is key; it must be taken as part of a lifestyle.
9
Rich in omega benefits
32 people found this helpful
This omega boasts a rich composition and exceptional quality. It helps lower blood cholesterol, reduces blood clot risks, and delivers various health benefits. The review highlights omega's positive impact on brain function and the immune system. If you match your diet with omega-3, you can enjoy its health advantages.
9
Antarctic krill oil aids cholesterol
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
8
Fish oil reduces liver fat accumulation
Fish oil consumption prevents hepatic lipid accumulation induced by high-cholesterol feeding in obese KK mice.
We investigated how fish oil (FO) affects liver fat accumulation in response to a high-cholesterol (CH) diet using KK mice. The study included groups that received either safflower oil or varying amounts of fish oil along with cholesterol over eight weeks.
The results showed that the group with the highest fish oil intake had significantly lower liver triglyceride and cholesterol levels compared to the group with only safflower oil. This suggests that fish oil may indeed help prevent fat accumulation in the liver linked to high cholesterol, reducing the risk of fatty liver disease.
9
Significant reduction in ischemic events
Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT.
We analyzed the effects of icosapent ethyl, a form of Omega 3 fish oil, on patients with high triglycerides and cardiovascular issues. The REDUCE-IT trial involved over 8,000 statin-treated patients and demonstrated that icosapent ethyl significantly reduced both the first and total ischemic events, which include serious heart conditions like heart attacks and strokes.
This means that those at risk saw meaningful benefits from this treatment. Overall, we found that icosapent ethyl could be a valuable option for improving heart health in patients struggling with high cholesterol and triglycerides.
4
Omega-3s show limited cardiovascular benefits
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
We examined how consuming more omega-3 fatty acids from fish and plants impacts heart disease risk. Our analysis focused on rigorous studies involving adults at risk of cardiovascular issues who received dietary supplements alongside guidance on increasing omega-3 intake.
Despite some benefits from omega-3 ALA in reducing CVD events, the overall results indicate that short-chain fatty acids and long-chain omega-3s had little effect on reducing heart-related mortality or improving cardiovascular health.
This suggests omega-3s may not be a magic bullet for heart health.
9
Omega-3 EPA+DHA improves cholesterol
EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
References
Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. 10.3390/nu16213614
Hirako S, Kim H, Iizuka Y, Matsumoto A. Fish oil consumption prevents hepatic lipid accumulation induced by high-cholesterol feeding in obese KK mice. Biomed Res. 2024;45:33. 10.2220/biomedres.45.33
Mjaatveit M, Oldernes H, Gudbrandsen OA. Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis. Br J Nutr. 2024;131:606. 10.1017/S0007114523002118
Zhang C, Wang X, Sun S, Fu Y, Wu Y, et al. Fat-1 expression alleviates atherosclerosis in transgenic rabbits. J Cell Mol Med. 2022;26:1306. 10.1111/jcmm.17188
Sugimoto K, Hosomi R, Shimono T, Kanda S, Nishiyama T, et al. Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice. J Oleo Sci. 2021;70:965. 10.5650/jos.ess21032
Jaca A, Durão S, Harbron J. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. S Afr Med J. 2020;110:1158. 10.7196/SAMJ.2020.v110i12.14730
Trivedi K, Le V, Nelson JR. The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention. Postgrad Med. 2021;133:28. 10.1080/00325481.2020.1783937
Saito M, Ishida N, Yamada H, Ibi M, Hirose M. 8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice. Biol Pharm Bull. 2020;43:919. 10.1248/bpb.b20-00162
Llop-Talaveron J, Badía-Tahull M, Lozano-Andreu T, Rigo-Bonnin R, Virgili-Casas N, et al. Phytosterolemia and γ-glutamyl transferase in adults with parenteral nutrition: Fish versus vegetal lipids: A randomized clinical trial. Nutrition. 2020;70:110587. 10.1016/j.nut.2019.110587
Antona ME, Ramos C, Stranges A, Monteiro AF, Gonzales Chaves MM, et al. Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats. Arch Oral Biol. 2020;109:104553. 10.1016/j.archoralbio.2019.104553
Zhou Q, Zhang Z, Wang P, Zhang B, Chen C, et al. EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mol Nutr Food Res. 2019;63:e1801157. 10.1002/mnfr.201801157
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, et al. Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT. J Am Coll Cardiol. 2019;73:2791. 10.1016/j.jacc.2019.02.032
Preston Mason R. New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease. Curr Atheroscler Rep. 2019;21:2. 10.1007/s11883-019-0762-1
Vikøren LA, Drotningsvik A, Bergseth MT, Mjøs SA, Austgulen MH, et al. Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain -3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats. Nutrients. 2018;10. 10.3390/nu10070840
Blom WAM, Koppenol WP, Hiemstra H, Stojakovic T, Scharnagl H, et al. A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. Eur J Nutr. 2019;58:1615. 10.1007/s00394-018-1706-1
Shen J, Rastogi R, Guan L, Li F, Du H, et al. Omega-3 fatty acid supplement reduces activation of NADPH oxidase in intracranial atherosclerosis stenosis. Neurol Res. 2018;40:499. 10.1080/01616412.2018.1451290